Vad är malt lymfom?

Innehållsförteckning:

1. Vad är malt lymfom?
2. What is MALT lymphoma?
3. What are the treatment options for metastatic gastric lymphoma (MALT)?
4. What is the Wotherspoon score for MALT lymphoma?
5. What is the role of endoscopy in the workup of MALT lymphoma?

Vad är malt lymfom?

Marginalzonslymfom (MZL) är en heterogen grupp lågmaligna lymfom som kan finnas i lymfkörtlar men oftare i annan vävnad som mjälte, benmärg och blod eller i slemhinnor. MZL som uppstår i slemhinnor kallas MALT-lymfom. MALT-lymfom är således en undergrupp till marginalzonslymfom.

What is MALT lymphoma?

Lymphoma is a cancer of the kinds of white blood cells known as lymphocytes. MALT lymphoma is an uncommon form of non-Hodgkin lymphoma (NHL). MALT stands for "mucosa-associated lymphoid tissue."

What are the treatment options for metastatic gastric lymphoma (MALT)?

Radiotherapy is a valid first option for MALT lymphoma. It provides local control and potential cure in localized gastric stage IE and II 1E disease with 5-year EFS of 85-100% reported in retrospective studies. However, the irradiation field is potentially large as it must include the whole stomach, which can vary greatly in size and shape.

What is the Wotherspoon score for MALT lymphoma?

The Wotherspoon score, which grades the presence of histological features associated with MALT lymphoma, is useful in expressing confidence in diagnosis at presentation. Immunohistochemistry can be used to help distinguish MALT lymphoma from other small B-cell NHLs.

What is the role of endoscopy in the workup of MALT lymphoma?

Endoscopy is key to diagnosing MALT lymphoma, with multiple biopsies of the visible lesions required, as well as samples of macroscopically normal tissue, termed gastric mapping. Histologically, there is expansion of the marginal zone compartment with development of sheets of neoplastic small lymphoid cells.